Fibronectin promotes wound healing in an atopic human skin xenografting model

Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by dry and itchy lesions that can be localized or extend over large portions of the body. Skin lesions in AD patients have increased expression of Th2 cytokines, and IL-4 promotes the pathogenesis of AD and skin fibrotic remodeling. Human skin biopsies and primary keratinocytes stimulated with IL-4 demonstrate diminished epidermal differentiation complex (EDC) gene expression (Howell et al., 2007). Our previous reports have shown that mutations of EDC genes and increased Th2 responses cooperate to exacerbate diminished barrier function in the Stat6VT Tg mouse model (Sehra et al., 2016, Sehra et al., 2010).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research