Immunomodulatory actions of myeloid-derived suppressor cells in the context of innate immunity

Innate Immun. 2023 Nov 28:17534259231215581. doi: 10.1177/17534259231215581. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) are notable innate immune cells, which are further divided into two subpopulations, i.e., monocytic and granulocytic. These cells are traditionally considered to mainly suppress the T-cell responses. However, more updated data indicate that their properties are rather immunomodulatory than solely immunosuppressive. Indeed, MDSCs display extensive crosstalk with other either innate or adaptive immune cells, and, according to the situation under which they are triggered, they may enhance or attenuate the immune response. However, their positive role in host's defense mechanisms under specific conditions is rarely discussed in the literature. In this mini-review, the authors briefly summarise the mechanisms of action of MDSCs under distinct conditions, such as infections and malignancies, with a particular emphasis on their role as components of the innate immunity system.PMID:38018014 | DOI:10.1177/17534259231215581

Source: Innate Immunity - November 29, 2023 Category: Allergy & Immunology Authors: Nikoleta Bizymi Andreas M Matthaiou Irene Mavroudi Aristea Batsali Helen A Papadaki Source Type: research