Beyond Forced Exhalation: Impulse Oscillometry as a Promising Tool for Bronchial Hyperresponsiveness Evaluation

J Asthma. 2023 Nov 24:1-11. doi: 10.1080/02770903.2023.2288316. Online ahead of print.ABSTRACTThe multiple forced expiratory manoeuvres that must be performed during methacholine test require a high degree of collaboration and can lead to fatigue. However, impulse oscillometry (IOS) is a non-invasive test, quick and easy to perform, that does not require effort-dependent maneuvers. The primary endpoint was to evaluate the relationship between IOS and spirometry during the methacholine test. The secondary endpoint was to study the predictive value of baseline IOS in the development of bronchial hyperreactivity.Observational, prospective, cross-sectional study, with recruitment of consecutive patients from the pulmonology department with clinical suspicion of bronchial asthma with negative bronchodilator test and normal FeNO.25 patients were included with a mean age of 49 ± 18 years. 13 patients (52%) had a positive methacholine test. The correlation between IOS indices and FEV1 was significant (P < 0.05) in all cases. The indexes with the highest predictive power were R5-20 and AX. The optimal cutoff points were an increase of greater than 32.96% in R5, greater than 120.83% for X5, an increase of 30.30% in R5-20 and an increase of 1.01 [kPa l-1] for AX. Baseline oscillometry had a strong predictive value in the development of bronchial hyperreactivity with a sensitivity of 61.5% and a specificity of 91.7% using the cut-off point of 160.0% for R5.IOS may be useful as an alt...
Source: Journal of Asthma - Category: Respiratory Medicine Authors: Source Type: research