Multi-parametric flow cytometry in the evaluation of plasma cell proliferative disorders- Current paradigms for clinical practice

Plasma cell proliferative disorders (PCPDs) comprise a spectrum of disorders arising from clonal plasma cells (PCs) with variable disease phenotype ranging from benign premalignant state of Monoclonal Gammopathy of Undetermined Significance (MGUS) to indolent state of Smoldering Multiple Myeloma (SMM) to overt malignant phenotype of Multiple Myeloma (MM), some of which may progress to a clinically aggressive leukemic state of Plasma Cell leukemia (PCL). In MGUS, SMM and MM, the primary disease is intramedullary whereas PCL has a hematogenous spread.

Source: Clinical Lymphoma, Myeloma and Leukemia - November 26, 2023 Category: Hematology Authors: Ritu Gupta, Dragan Jevremovic, Smith J. Mathew, Shaji Kumar Tags: Review Article Source Type: research