Carbon recycling with synthetic CO < sub > 2 < /sub > fixation pathways

Curr Opin Biotechnol. 2023 Nov 25;85:103023. doi: 10.1016/j.copbio.2023.103023. Online ahead of print.ABSTRACTCarbon dioxide (CO2) is the node of alleviating global climate change and supporting living organisms on Earth. Currently, the warming climate and the growing population demand enhanced CO2 fixation for a sustainable future, which stimulates innovations in biotechnology to tackle these challenges. To this endeavor, synthetic biology and metabolic engineering are enabling a promising approach to engineer synthetic carbon fixation in heterotrophic organisms combining the advantages of both autotrophs and heterotrophs. Here, we review the current advances in constructing synthetic CO2 fixation pathways and discuss the underlying design principles with confronting challenges. Moreover, we highlight the application scenarios of these designs at different concentrations of CO2, and how sustainable bioproduction can be improved. We also foresee the future of engineering synthetic carbon fixation pathways for carbon recycling.PMID:38007984 | DOI:10.1016/j.copbio.2023.103023

Source: Current Opinion in Biotechnology - November 26, 2023 Category: Biotechnology Authors: Pei-Ru Chen Peng-Fei Xia Source Type: research