E. coli ´s fight against TYROnny: Designing a bacterial strain to tackle tyrosinemia type 1

Tyrosinemia type 1 (HT-1) is a rare autosomal recessive disease caused by a deficiency of fumarylacetoacetate hydrolase (FAH)1,2 and occurs in approximately 1 in 100,000 newborns3. The lack of FAH leads to an increase of intermediary products when degrading the amino acids phenylalanine and tyrosine to fumarate and acetoacetate2 (Figure 1a). Next to the name-giving increase of tyrosine levels in the sera of patients suffering from this disease, an elevation of fumarylacetoacetate (FAA), the direct substrate of FAH, can be detected2 (Figure 1b).

Source: Journal of Hepatology - November 23, 2023 Category: Gastroenterology Authors: J öran Lücke, Samuel Huber Tags: Editorial Source Type: research