Mouse retrotransposons: sequence structure, evolutionary age, genomic distribution and function

Genes Genet Syst. 2023 Nov 22. doi: 10.1266/ggs.23-00221. Online ahead of print.ABSTRACTRetrotransposons are transposable elements that are transposed via transcription and reverse transcription. Their copies have accumulated in the genome of mammals, occupying approximately 40% of mammalian genomic mass. These copies are often involved in numerous phenomena, such as chromatin spatial organization, gene expression, development and disease, and have been recognized as a driving force in evolution. Different organisms have gained specific retrotransposon subfamilies and retrotransposed copies, such as hundreds of Mus-specific subfamilies with diverse sequences and genomic locations. Despite this complexity, basic information is still necessary for present-day genomic and epigenomic studies. Herein, we describe the characteristics of each subfamily of Mus-specific retrotransposons in terms of sequence structure, phylogenetic relationships, evolutionary age, and preference for A or B compartments of chromatin.PMID:37989301 | DOI:10.1266/ggs.23-00221

Source: Genes and Genetic Systems - November 21, 2023 Category: Genetics & Stem Cells Authors: Masaki Kawase Kenji Ichiyanagi Source Type: research