Alternative Routes of Surfactant Application – an Update

Non-invasive modes of respiratory support have been shown to be the preferable way of primary respiratory support of preterm infants with respiratory distress syndrome (RDS). The avoidance of invasive mechanical ventilation can be beneficial for preterm infants in reduction of morbidity and even mortality. However, it is well-established that some infants managed with non-invasive respiratory support from the outset have symptomatic RDS to a degree that warrants surfactant administration. Infants for whom non-invasive respiratory support ultimately fails are prone to adverse outcomes, occurring at a frequency on par with the group intubated primarily.

Source: Seminars in Fetal and Neonatal Medicine - November 21, 2023 Category: Perinatology & Neonatology Authors: Angela Kribs, Kari D. Roberts, Daniele Trevisanuto, Colm O-Donnell, Peter A. Dargaville Source Type: research