How important is the linearity assumption in a sample size calculation for a randomised controlled trial where treatment is anticipated to affect a rate of change?

For certain conditions, treatments aim to lessen deterioration over time. A trial outcome could be change in a continuous measure, analysed using a random slopes model with a different slope in each treatment ...

Source: BMC Medical Research Methodology - November 21, 2023 Category: Research Authors: Katy E. Morgan, Ian R. White and Chris Frost Tags: Research Source Type: research