Redox-Sensitive High-Mobility Group Box-1 Isoforms Contribute To Liver Fibrosis Progression And Resolution In Mice

High-mobility group box-1 (HMGB1) significantly increases and undergoes post-translational modifications (PTMs) in response to liver injury. Since oxidant stress plays a major role in liver fibrosis and induces PTMs in proteins, we hypothesized that redox-sensitive HMGB1 isoforms contribute to liver fibrosis progression and resolution.

Source: Journal of Hepatology - November 19, 2023 Category: Gastroenterology Authors: Xiaodong Ge, Romain Desert, Fernando Magdaleno, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Wei Chen, Ines Barahona, Daniel Lantvit, Hui Chen, Sunil Hwang, Natalia Nieto Tags: Research Article Source Type: research