Denosumab Induces Neoplastic Stromal Cell Apoptosis via p62 Downregulation Dependent on Autophagy Pathway in Giant Cell Tumour of Bone

CONCLUSION: Denosumab induced neoplastic stromal cells apoptosis via p62 downregulation dependent on autophagy pathway. The combination of p62 and RANKL knockdown might be a better strategy than RANKL knockdown alone for GCTB targeted therapy.PMID:37961860 | DOI:10.2174/0115680096265253231022185008

Source: Current Cancer Drug Targets - November 14, 2023 Category: Cancer & Oncology Authors: Xianwei Chen Fan Ye Hao He Gong Chen Zhifu Chen En Ye Bingjan He Yuqi Yang Jing Zhang Source Type: research