N-of-one differential gene expression without control samples using a deep generative model

Differential analysis of bulk RNA-seq data often suffers from lack of good controls. Here, we present a generative model that replaces controls, trained solely on healthy tissues. The unsupervised model learns...

Source: Genome Biology - November 16, 2023 Category: Genetics & Stem Cells Authors: I ñigo Prada-Luengo, Viktoria Schuster, Yuhu Liang, Thilde Terkelsen, Valentina Sora and Anders Krogh Tags: Method Source Type: research