CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence

CDK4/6 inhibitors, used to treat metastatic breast cancer, can have long-term anti-proliferative effects, even after patients finish treatment. Crozier et  al. show that CDK4/6 inhibitors block cell proliferation but not growth. This causes cell overgrowth, leading to biphasic cellular stress responses that drive permanent cell-cycle withdrawal.

Source: Molecular Cell - November 16, 2023 Category: Cytology Authors: Lisa Crozier, Reece Foy, Rozita Adib, Ananya Kar, Jordan A. Holt, Aanchal U. Pareri, Juan Manuel Valverde, Rene Rivera, William A. Weston, Rona Wilson, Clement Regnault, Phil Whitfield, Mihaly Badonyi, Laura G. Bennett, Ellen G. Vernon, Amelia Gamble, Jos Tags: Article Source Type: research