New insights into chronic rhinosinusitis associated with IgG4-related disease

IgG4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized by elevated IgG4 serum levels, abundant IgG4-positive plasmacyte infiltration, and fibrosis of various organs, including the head and neck. We aimed to provide an overall review of IgG4-RD in the sinonasal region and propose a novel entity and criteria of chronic rhinosinusitis (CRS) associated with IgG4-RD as “IgG4-CRS,” a distinct manifestation of IgG4-RD in the sinonasal region. Sinonasal involvement has been increasingly recognized; however, this region is not included in the classic IgG4-RD-affected organs.

Source: Auris, Nasus, Larynx - November 14, 2023 Category: ENT & OMF Authors: Kenichi Takano, Ryuta Kamekura, Tsuyoshi Okuni, Keisuke Yamamoto Source Type: research