Hiding from allogeneic NK cells and macrophages by a synthetic receptor

Cell Stem Cell. 2023 Nov 2;30(11):1393-1394. doi: 10.1016/j.stem.2023.10.005.ABSTRACTImmune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.1 utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named "synthetic immune checkpoint engager," to prevent attack from NK cells and macrophages.PMID:37922874 | DOI:10.1016/j.stem.2023.10.005

Source: Cell Stem Cell - November 3, 2023 Category: Stem Cells Authors: Akitsu Hotta Joseph Lee Source Type: research