A Critical Review on Therapeutic Potential of Benzimidazole Derivatives: A Privileged Scaffold

Med Chem. 2023 Nov 8. doi: 10.2174/0115734064253813231025093707. Online ahead of print.ABSTRACTBenzimidazole nucleus is a predominant heterocycle displaying a wide spectrum of pharmacological activities. The privileged nature of the benzimidazole scaffold has been revealed by its presence in most small molecule drugs and in its ability to bind multiple receptors with high affinity. A literature review of the scaffold reveals several instances where structural modifications of the benzimidazole core have resulted in high-affinity lead compounds against a variety of biological targets. Hence, this structural moiety offers opportunities to discover novel, better, safe and highly potent biological agents. The goal of the present review is to compile the medicinal properties of benzimidazole derivatives with a focus on SAR (Structure-Activity Relationships).PMID:37946342 | DOI:10.2174/0115734064253813231025093707

Source: Medicinal Chemistry - November 10, 2023 Category: Chemistry Authors: N Ramalakshmi K Padma S Arunkumar S Amuthalakshmi Prabakaran A Richie R Bhandare Afzal B Shaik Source Type: research