Iridium-Catalyzed Ligand-Controlled Semi-Reduction of Alkynes Employing H2O as the Hydrogen Donor and Its Application

Synlett DOI: 10.1055/s-0042-1751516 An iridium-catalyzed ligand-controlled semi-reduction of alkynes employing H2O as the hydrogen donor, together with its application, is reported. The use of di-tert-butylphosphinous chloride is crucial for stereoselectivity toward Z-olefins, whereas the use of 2-(diphenylphosphino)benzaldehyde is crucial for stereoselectivity toward E-olefins. More than 35 alkenes were obtained in good yields and high stereoselectivities. The utility of the current method in practical applications was investigated by studying the drug effects of (E)-1,3-dimethoxy-5-styrylbenzene on nerve growth in a zebrafish model. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - November 2, 2023 Category: Chemistry Authors: Zhao, Wei Zhou, Siyi Wang, Chengniu Zhang, Yi Xu, Dawei Tags: letter Source Type: research