Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain

The NiRAN domain in SARS-CoV-2 has been implicated as the enzyme responsible for capping of viral mRNA and NMPylation of nsp9. Small and colleagues reveal the structural basis of mRNA capping and NMPylation of nsp9 and describe how the NiRAN domain catalyzes such distinct activities in the same active site.

Source: Molecular Cell - October 26, 2023 Category: Cytology Authors: Gabriel I. Small, Olga Fedorova, Paul Dominic B. Olinares, Joshua Chandanani, Anoosha Banerjee, Young Joo Choi, Henrik Molina, Brian T. Chait, Seth A. Darst, Elizabeth A. Campbell Tags: Article Source Type: research