TAK1 is an essential kinase for STING trafficking

Ma, Dang, and Chang et  al. uncovered a STING-mediated activation of TAK1 at the ER, which in turn induces STING phosphorylation and initiates STEEP-mediated STING trafficking. These findings shed light on an early signaling event in the regulation of STING exit from ER.

Source: Molecular Cell - October 12, 2023 Category: Cytology Authors: Mingtong Ma, Yifang Dang, Boran Chang, Fei Wang, Junfang Xu, Li Chen, Hang Su, Jinsong Li, Baoxue Ge, Chang Chen, Haipeng Liu Tags: Article Source Type: research