Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

Wang, Sass et  al. determine structures of the CCT-Gβ5-PhLP1 complex that reveal Gβ5 folding intermediates ranging from a molten globule to a fully folded β-propeller. These intermediates define a Gβ5 folding trajectory guided by CCT interactions with surface residues that allow the hydrophobic core to coale sce into its folded state.

Source: Molecular Cell - October 17, 2023 Category: Cytology Authors: Shuxin Wang, Mikaila I. Sass, Yujin Kwon, W. Grant Ludlam, Theresa M. Smith, Ethan J. Carter, Nathan E. Gladden, Margot Riggi, Janet H. Iwasa, Barry M. Willardson, Peter S. Shen Tags: Article Source Type: research