Disordered protein regions partner up the cBAF remodeler for a chromatin dance

Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et  al.1 decode how such regions within the chromatin remodeler cBAF choreograph self-condensation and non-self interactions with transcriptional regulators, potentially impacting disease.

Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Maren Heimhalt, Andreas G. Ladurner Tags: Spotlight Source Type: research