A domain of all trades: The enzymatic versatility of the NiRAN domain

The SARS-CoV-2 NiRAN domain is essential for viral replication. Despite adopting a pseudokinase fold, it catalyzes three distinct biochemical reactions from a single active site. In this issue of Molecular Cell, Small et  al.1 elucidate the structural intricacies of the NiRAN domain shedding light on the factors that underlie its remarkable versatility.

Source: Molecular Cell - November 2, 2023 Category: Cytology Authors: Adam Osinski, Vincent S. Tagliabracci Tags: Preview Source Type: research