13. HPV forms chimeric virus-human transcripts that affect host gene expression in cervical tumors

Cervical cancer is a common gynecological tumor, primarily caused by HPV infection. Integration of HPV into the human genome allows aberrant expression of HPV oncogenes E6 and E7. However, whether HPV-human gene fusions arise from these events and their effects on human gene partners are less studied.

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Kay Jayachandran, Rashmi Pillai, Matthew Inkman, Fiona Ruiz, Jace Webster, Julie Schwarz, Christopher Maher, Jin Zhang Source Type: research