19. Developing a generalized model for variants in CIViC

Increased clinical use of next generation sequencing has generated a variant interpretation bottleneck. CIViC (Clinical Interpretations of Variants in Cancer; civicdb.org) addresses this problem by leveraging crowdsourced literature and abstract curation with expert moderation in a completely free and open worldwide resource. The CIViC data model incorporates established and emerging guidelines for classification, and associates evidence to single or multi-variant Molecular Profiles (MPs).Large-scale alterations involving multiple genes and non-genic regions are clinically important in multiple cancers.

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Arpad Danos, Kilannin Krysiak, Jason Saliba, Susanna Kiwala, Joshua McMichael, Adam Coffman, Cameron Grisdale, Mariam Khanfar, Obi Griffith, Malachi Griffith Source Type: research