61. A cell-free DNA 5-hydroxymethylcytosine marker predicts immunotherapy response in lung cancer

Novel predictive markers facilitate effective lung cancer treatment. Immune checkpoint inhibitors (ICIs) can drastically improve outcomes for lung cancer patients. However, currently no markers can accurately predict which patients will benefit from ICI therapies. We performed a genome-wide analysis of 5-hydroxymethylcytosine (5hmC) in 71 plasma cell-free DNA (cfDNA) samples from lung cancer patients. Using machine learning approaches, we developed a 5hmC signature for ICI treatment prediction in lung cancer in a training set and validated it in a validation set.

Source: Cancer Genetics and Cytogenetics - November 1, 2023 Category: Genetics & Stem Cells Authors: Zejuan Li, Jianming Shao, Randall Olsen, Saro Kasparian, Chuan He, Eric Bernicker Source Type: research