Differences of RUNX2 gene promoter methylation and transcription level in ankylosing spondylitis

ConclusionThe RUNX2 gene promoter was hypomethylated in AS patients. Meanwhile, the qRT-PCR verified the up-regulated expression on the transcription level, suggesting the abnormal methylation of RUNX2 contributes to the pathogenesis of AS.

Source: International Journal of Rheumatic Diseases - October 30, 2023 Category: Rheumatology Authors: Feier Wang, Yuting Chen, Jiangping Kong, Shanshan Xu, Shengqian Xu, Zongwen Shuai, Guoqi Cai, Faming Pan Tags: ORIGINAL ARTICLE Source Type: research