A platform for qualitative and quantitative characterization of α-Gal and NeuGc at the oligosaccharide level

This study introduces a sensitive and reliable analytical approach for the qualitative and quantitative assessment of α-Gal and NeuGc in glycoprotein pharmaceuticals. The methodology offers significant potential for application in process control and optimization of glycoprotein production, aimed at minimizing immunogenicity and enhancing product quality.PMID:37866525 | DOI:10.1016/j.ab.2023.115362

Source: Analytical Biochemistry - October 22, 2023 Category: Biochemistry Authors: Weicheng Ren Lan Yang Jia Feng Shuyue Wang Qi Hu Hailong Liu Jinliang Zhang Zhiwei Wang Menghan Yan Hongwei Yu Yingwu Wang Source Type: research