ATG12-ATG5-TECPR1: an alternative E3-like complex utilized during the cellular response to lysosomal membrane damage

Autophagy. 2023 Oct 23:1-2. doi: 10.1080/15548627.2023.2267414. Online ahead of print.ABSTRACTATG16L1 is an essential component of the Atg8-family protein conjugation machinery, providing membrane targeting for the ATG12-ATG5 conjugate. Recently, we identified an alternative E3-like complex that functions independently of ATG16L1. This complex utilizes the autophagosome-lysosome tethering factor TECPR1 for membrane targeting. TECPR1 is recruited to damaged lysosomal membranes via a direct interaction with sphingomyelin. At the damaged membrane, TECPR1 assembles into an E3-like complex with ATG12-ATG5 to regulate unconventional LC3 lipidation and promote efficient lysosomal repair.PMID:37872727 | DOI:10.1080/15548627.2023.2267414

Source: Autophagy - October 24, 2023 Category: Cytology Authors: Dale P Corkery Yao-Wen Wu Source Type: research