The Function and Modification of Human Defensin 5

Protein Pept Lett. 2023 Oct 9. doi: 10.2174/0109298665252235230919071229. Online ahead of print.ABSTRACTThe antibacterial and antiviral functions of human defensin 5 lay the foundation for its role as a core host protective component. In addition, HD5 also has the function of inhibiting tumor proliferation and immune regulation. However, everything has two sides; cytotoxic and proinflammatory properties may exist, while HD5 performs physiological functions. Accordingly, the modification and engineering of HD5 are particularly important. Therefore, this review summarizes the role of HD5 in various aspects of host defense, as well as modification of HD5 to ameliorate the biological activity, with a view to promoting the clinical use of HD5.PMID:37861034 | DOI:10.2174/0109298665252235230919071229

Source: Protein and Peptide Letters - October 20, 2023 Category: Biochemistry Authors: Xin-Yue Chang Meng-Wei Meng Lin-Jie Zhang Lian-Qin Chai Source Type: research