MiR223-3p Promotes Genomic Stability of Hematopoietic Progenitors After Radiation

Most ionizing radiation (IR) DNA damage is repaired by the classical non-homologous end-joining (cNHEJ) or the conservative homologous recombination (HR) pathway, but when damage is extensive, a back-up pathway termed alternative Non-Homologous End Joining (aNHEJ) is activated (1-3). The rate limiting step in aNHEJ is when PARP1 successfully competes with the Ku complex for a free DNA end of a double strand break (DSB) (4). While aNHEJ can rapidly repair DSBs, this mechanism often results in deletions at the site of end-joining due to trimming of overhanging DNA strands after microhomology annealing (4).

Source: Experimental Hematology - October 22, 2023 Category: Hematology Authors: Shi Chen, Gayathri Srinivasan, Aruna Jaiswal, Elizabeth A. Williamson, Lingxiao Li, Dominic Arris, Daohong Zhou, Mingjiang Xu, Robert Hromas Tags: Brief Communication Source Type: research