Fork restart: unloading FANCD2 to travel ahead

In this issue of Molecular Cell, Brunner et  al.6 reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment.
Source: Molecular Cell - Category: Cytology Authors: Tags: Preview Source Type: research