Fork restart: unloading FANCD2 to travel ahead
In this issue of Molecular Cell, Brunner et al.6 reveal that eliminating FANCD2 from stalled forks via FBXL12-mediated degradation enables cells to tolerate oncogene-induced replication stress, making FBXL12 a promising target for cancer treatment.
Source: Molecular Cell - Category: Cytology Authors: Divya R. Iyer, Alan D. D ’Andrea Tags: Preview Source Type: research