ATR takes a crack at the nuclear envelope

In this issue, Joo et  al.1 and Kovacs et al.2 report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death.

Source: Molecular Cell - October 19, 2023 Category: Cytology Authors: Marcus B. Smolka, Jan Lammerding Tags: Preview Source Type: research