Cluster Gauss ‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models

In this study, we propose a method that approximates the profile likelihood by reusing intermediate computation results from CGNM, allowing us to obtain the upper bounds of the profile likelihood without conducting additional model evaluation. This method allows us to quickly draw approximate profile likelihoods for all unknown parameters. Additionally, the same approach can be used to draw two-dimensional profile likelihoods for all parameter combinations within seconds. We demonstrate the effectiveness of this method on three PBPK models.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ARTICLE Source Type: research