The latest model has just arrived! A new experimental mouse model of PLA2R1-associated membranous nephropathy

Much akin to the explosion in number of known target antigens in membranous nephropathy, there has been a rapid expansion in the availability of animal models involving the first 2 antigens discovered in adult disease, phospholipase A2 receptor and thrombospondin type 1 domain-containing 7A. In this issue, Tomas et  al. describe a novel mouse model of phospholipase A2 receptor–associated membranous nephropathy that shows great promise for investigating molecular mechanisms of disease and as an experimental system for testing existing and emerging therapies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research