Semi-rational engineering an aldo –keto reductase for stereocomplementary reduction of α-keto amide compounds

Enantio-pure α-hydroxy amides are valuable intermediates for the synthesis of chiral pharmaceuticals. The asymmetric reduction of α-keto amides to generate chiral α-hydroxy amides is a difficult and challengin...

Source: Microbial Cell Factories - October 15, 2023 Category: Microbiology Authors: Ruixuan Bai, Baoling Chen and Liangyu Zheng Tags: Research Source Type: research