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A combination of thermodynamic analysis, X-ray crystallography, and molecular dynamics (MD) simulations have revealed the molecular mechanism by which an arginine cluster introduced in the framework region of an Fab antibody enhanced affinity toward its antigen. For details, see: Shingo Maeta et al., Protein Science, 2023.https://doi.org/10.1002/pro.4745

https://onlinelibrary.wiley.com/doi/10.1002/pro.4799?af=R

Source: Protein Science - October 14, 2023 Category: Biochemistry Tags: Cover Image Source Type: research

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