Glomerular-tubular crosstalk via cold shock Y-box binding protein-1 in the kidney

Glomerular-tubular crosstalk within the kidney has been proposed, but the paracrine signals enabling this remain largely unknown. The cold-shock protein Y-box binding protein 1 (YBX1) is known to regulate inflammation and kidney diseases but its role in podocytes remains undetermined. Therefore, we analyzed mice with podocyte specific Ybx1 deletion (Ybx1 ΔPod). Albuminuria was increased in unchallenged Ybx1ΔPod mice, which surprisingly was associated with reduced glomerular, but enhanced tubular damage.

Source: Kidney International - September 27, 2023 Category: Urology & Nephrology Authors: Rajiv Rana, Jayakumar Manoharan, Ahmed Elwakiel, Silke Zimmermann, Jonathan A. Lindquist, Dheerendra Gupta, Moh'd Mohanad Al-Dabet, Ihsan Gadi, J örg Fallmann, Kunal Singh, Anubhuti Gupta, Ronald Biemann, Sabine Brandt, Bekas Alo, Paul Kluge, Ravindra Ga Tags: Basic Research Source Type: research