A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery

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A bifurcated guanidylated small molecule is modelled to access different clusters of sulphate esters in proteoglycans bound to the cell surface. Modular synthesis gives ready access to these molecules which have potential for the delivery of siRNA.

Source: Chemical Biology and Drug Design - January 28, 2014 Category: Biology Authors: Matt Gooding, Derick Adigbli, A. W. Edith Chan, Roberta J. Melander, Alexander J. MacRobert, David L. Selwood Tags: Research Article Source Type: research