Evaluation of a preservative-free, cross-linked sodium hyaluronate-based solution, Lacri  +®, in dogs with dry eye: a pilot trial

AbstractBackgroundThe purpose of this pilot trial was to evaluate the efficacy and benefits of a preservative-free cross-linked sodium hyaluronate solution (Lacri  +®, MP Labo, France) in 19 privately-owned dogs with dry eye. The animals were administered 2 drops of the tested product in each affected eye, twice a day (BID) for 30  days. Improvement in the global ocular clinical score (sum of the individual scores for conjunctivitis, ocular discharge, eye irritation, and corneal opacity/pigmentation/vascularization, each rated from 0 to 3) was defined as the primary outcome. Besides an improvement in each individual ocular s core, tear film quality (Tear Break Up Time, TBUT), dogs’ and owners’ quality of life (QoL), as well as an increase in tear production (Schirmer Tear Test-1, STT1), were considered secondary outcomes. These criteria were assessed on D0, D0 + 15 days, and D0 + 30 days. Finally, a qualit ative evaluation of clinical improvement was requested from the owners on D0 + 2, + 15&  + 30 days and from the investigators during the follow-up.ResultsThe global clinical ocular score as well as the individual conjunctival and irritation scores improved significantly (p <  0.0001) during the pilot trial. The average reduction of the global score reached 30% on D0 + 15 days and 55% on D0 + 30 days compared to D0. Ocular discharge was significantly lower (p = 0.0002) on D0 + 30 days compared to baseline; however ...
Source: Irish Veterinary Journal - Category: Veterinary Research Source Type: research