GI highlights from the literature

Basic scienceA multi-omics approach for revealing the crosstalk between the carbohydrate metabolism by gut microbiota and the insulin resistance Takeuchi T, Kubota T, Nakanishi Y, et al. Gut microbial carbohydrate metabolism contributes to insulin resistance. Nature 2023;6217978:389–95. doi: 10.1038/s41586-023-06466-x. Carbohydrate metabolism by the gut microbiota has been proposed to contribute to the pathogenesis of obesity and pre-diabetes, but the mechanistic linkage remains unexplained in humans. Takeuchi et al, employed a multi-omics approach, combined the faecal metabolome, the gut microbiome and the host pathology of insulin-resistant (IR) participants to identify the pathogenic gut microbial metabolites compared with individuals with normal insulin sensitivity (IS). The faecal carbohydrates, particularly monosaccharides, accounted for the most of IR-associated co-abundance groups. The analysis on the gut microbial composition at the genus level has clustered participants into four groups. A significantly lower proportion of IR individuals was identified in participants having a Bacteroidales-dominated gut...

Source: Gut - October 6, 2023 Category: Gastroenterology Authors: Smith, P. J. Tags: Gut JournalScan Source Type: research