RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1 β- and RNA-dependent co-activator of osteoclast gene expression

Nuclear receptor co-repressor (NCoR) is found to maintain normal bone density by co-activating RANKL-dependent gene transcription in osteoclasts. Abe et  al. resolve this paradox by demonstrating that RANKL induces RNA-dependent assembly of an NCoR/HDAC3/PGC1β complex that co-activates NF-κB and AP-1 target genes required for osteoclast differentiation.

Source: Molecular Cell - September 25, 2023 Category: Cytology Authors: Yohei Abe, Eric R. Kofman, Maria Almeida, Zhengyu Ouyang, Filipa Ponte, Jasmine R. Mueller, Grisel Cruz-Becerra, Mashito Sakai, Thomas A. Prohaska, Nathanael J. Spann, Ana Resende-Coelho, Jason S. Seidman, Joshua D. Stender, Havilah Taylor, Weiwei Fan, Ve Tags: Article Source Type: research