STING channels its proton power

Induction of type I interferon by the STING pathway is a cornerstone of innate immunity. STING also turns on non-canonical autophagy and inflammasome activation although the underlying mechanisms remain ill defined. Liu et  al.1 discovered that STING forms a channel that directs proton efflux from the Golgi to drive these responses.

Source: Molecular Cell - October 5, 2023 Category: Cytology Authors: Mingqi Dong, Katherine A. Fitzgerald Tags: Spotlight Source Type: research