How the circadian nuclear orphan receptor REV-ERB α represses transcription: Temporal and spatial phase separation combined

In this issue of Molecular Cell, Zhu et  al.1 demonstrate that REV-ERBα and its co-repressor NCOR1 are assembled into daytime-dependent liquid droplets that constitute hubs in which the transcription of multiple REV-ERBα target genes is simultaneously repressed.

Source: Molecular Cell - October 5, 2023 Category: Cytology Authors: Ueli Schibler Tags: Preview Source Type: research