An updated view of the kinetochore architecture

Trends Genet. 2023 Sep 27:S0168-9525(23)00220-2. doi: 10.1016/j.tig.2023.09.003. Online ahead of print.ABSTRACTThe kinetochore is a supramolecular complex that facilitates faithful chromosome segregation by bridging the centromere and spindle microtubules. Recent functional and structural studies on the inner kinetochore subcomplex, constitutive centromere-associated network (CCAN) have updated our understanding of kinetochore architecture. While the CCAN core establishes a stable interface with centromeric chromatin, CCAN organization is dynamically altered and coupled with cell cycle progression. Furthermore, the CCAN components, centromere protein (CENP)-C and CENP-T, mediate higher-order assembly of multiple kinetochore units on the regional centromeres of vertebrates. This review highlights new insights into kinetochore rigidity, plasticity, and clustering, which are key to understanding temporal and spatial regulatory mechanisms of chromosome segregation.PMID:37775394 | DOI:10.1016/j.tig.2023.09.003

Source: Trends in Genetics : TIG - September 29, 2023 Category: Genetics & Stem Cells Authors: Mariko Ariyoshi Tatsuo Fukagawa Source Type: research