Hepatocyte nuclear factor 4 α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.

Nicotinamide adenine dinucleotide (NAD+) levels decline in experimental models of acute kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular epithelium may contribute to adverse cellular and physiological outcomes. Mechanisms underlying defense of tryptophan-dependent NAD+ production are incompletely understood. Here we show that regulation of a bottleneck enzyme in this pathway, quinolinate phosphoribosyltransferase (QPRT) may contribute to kidney resilience. Expression of QPRT declined in two unrelated models of AKI.

Source: Kidney International - September 29, 2023 Category: Urology & Nephrology Authors: Amanda J. Clark, Marie Christelle Saade, Vamsidhara Vemireddy, Kyle Q. Vu, Brenda Mendoza Flores, Valerie Etzrodt, Erin J. Ciampa, Huihui Huang, Ayumi Takakura, Kambiz Zandi-Nejad, Zsuzsanna K. Zsengell ér, Samir M. Parikh Tags: basic research Source Type: research