The basal ganglia are a target for sensorimotor domains in posterior parietal, premotor, and motor cortex in primates

Curr Opin Neurobiol. 2023 Sep 19;83:102783. doi: 10.1016/j.conb.2023.102783. Online ahead of print.ABSTRACTOur research focused on defining and characterizing parieto-frontal circuits for specific actions in primates. Part of the posterior parietal cortex is divided into eight or more domains where electrical stimulation evokes a meaningful complex movement. Domains in the posterior parietal cortex compete with each other over excitatory connections that activate inhibitory neurons, while selectively activating functionally matched domains in the premotor cortex and motor cortex. Thus, the selection process involves competition and cooperation between domains over three different regions of cortex. In addition, projections from functionally matched domains in motor regions converge in the matrix of the striatum, whereas projections from different functionally unmatched domains are separate. Thus, the projections of action-specific domains include the basal ganglia, where actions can be permitted or blocked.PMID:37734361 | DOI:10.1016/j.conb.2023.102783

Source: Current Opinion in Neurobiology - September 21, 2023 Category: Neurology Authors: Jon Kaas Iwona Stepniewska Source Type: research