At the Right Dose: Personalized (N-of-1) dosing for precision oncology

The objective of oncology therapeutics, especially in the age of precision medicine, is to give the right drug(s) to the right patient at the right time. Yet, a major challenge is finding the right dose for each patient. Determining safe and efficacious doses of oncology treatments, especially for novel combination therapies, can be challenging. Moreover, traditionally, dosing cancer drugs is based on giving each patient the same dose (a flat dose) or a dose based on surface area/weight. But patients ’ ability to tolerate drugs is influenced by additional factors including, but not limited to age, gender, race, co-morbidities, organ function, and metabolism.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Current Perspective Source Type: research