Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata

AbstractDaphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated fromDaphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses combined with synthetic methods, including methyl esterification, derivatization reaction using a chiral anisotropic agent, and biomimetic conversion. Compounds1 and2 along with their methyl esters1a and2a were evaluated for anti-HIV activity, among which1a and2a exhibited potent activity with IC50 values of 1.08 and 1.17  μM, respectively.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research