Shape Control of Carbon Nanoparticles via Simple Anion-Directed Strategy for Precise Endoplasmic Reticulum-Targeted Imaging

Angew Chem Int Ed Engl. 2023 Sep 14:e202311008. doi: 10.1002/anie.202311008. Online ahead of print.ABSTRACTHerein, small-sized fluorescent carbon nanoparticles (CNs) with tunable shapes ranging from spheres to various rods with aspect ratios (ARs) of 1.00, 1.51, 1.89, and 2.85 are prepared using a simple anion-directed strategy for the first time. And based on comprehensive morphological and structural characteristics of CNs, along with theoretical calculations of density functional theory and molecular dynamics simulations, their shape-control mechanism is attributed to interionic interactions-induced self-assembly, followed by carbonization. Interestingly, the endoplasmic reticulum-targeting accuracy of CNs gradually enhances as their shape changes from spherical to higher-AR rods, accompanied by a Pearson's correlation coefficient up to 0.90.This work presents a facile approach to control the shape of CNs and reveals the relationship between the shape and organelle-targeting abilities of CNs, thereby providing a novel idea to synthesize CNs that serve as precise organelle-targeted fluorescence probes.PMID:37707496 | DOI:10.1002/anie.202311008
Source: Angewandte Chemie - Category: Chemistry Authors: Source Type: research