Bromination of Triacanthine

Bromination of the purine alkaloid triacanthine byN-bromosuccinimide in CHCl3, AcOH, and various alcohols was studied. The new derivatives 8-bromo-, 12,13-dibromo-, 8,12-dibromo-13-hydroxymethyl-, hydroxyethyl-, hydroxypropyl-, and hydroxybutyltriacanthine were prepared. The structures of the prepared compounds were proven using1H and13C NMR spectral data and X-ray crystal structure analyses.

Source: Chemistry of Natural Compounds - September 13, 2023 Category: Chemistry Source Type: research